BA.1とBA.2の合体変異株なるものが出てきたとも・・・
今日のゲノム解析の結果、前半だけですがT19I, L24S, Δ25/27, A67V無し, Δ69/70無し, T95I無し, del143/145無し,Δ211無し, L212I無し, ins214EPE無し, V213G,なのでBA.2で間違いなさそうです。おそらく市中感染。残念ですがこれが現実です（一応Δ25/27の証拠も pic.twitter.com/4LdsHktDj3
— 研究者「」@1copyからのRT-PCR (@uwemon) February 10, 2022
数日前に手元に来るかもしれないというツイートをしたばかりでした。我々のレベルの数でも検出されたと言う事はBA.2の市中感染が進んでいることを示しているように思えます。BA.2が存在するという事実から、ο株を前提とした対策を直ちに修正する必要があると考えます。ピークアウトどころではない危機
— 研究者「」@1copyからのRT-PCR (@uwemon) February 10, 2022
臨床の先生方もBA.2の情報を収集し対応する準備をしておいてください。SGTFで変異を調べている方は全てがο株だと思い込まずに面倒でも続けて下さい。必ず怪しい結果が出てきます。その時はゲノム解析を行って下さい。決して無視をしてはいけない変異株です。敏感になっておきましょう。
— 研究者「」@1copyからのRT-PCR (@uwemon) February 10, 2022
たった3日前のツイートhttps://t.co/lU6S7wy7td
— 研究者「」@1copyからのRT-PCR (@uwemon) February 10, 2022
5日前のツイート。この時にシークエンスの特徴を勉強しておいて良かったです。おかげで一目でわかりましたhttps://t.co/y8ehZN3sga
— 研究者「」@1copyからのRT-PCR (@uwemon) February 10, 2022
Ericさんの昨日のツイートを参考までにツリーに繋げておきます。https://t.co/sbo2gLJe5F
— 研究者「」@1copyからのRT-PCR (@uwemon) February 10, 2022
⚠️SUB-VARIANT SURGING—Omicron 2.0 is rising—the #BA2 sublineage of #Omicron has *tripled* in one week, dislodging the old Omicron from total dominance—BA2 now at 3.6% and climbing fast. Expect to be dominant by March. Omicron reinfections are possible. 🧵 https://t.co/amAjDWuN6Z pic.twitter.com/dU8ewDhii1
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
2) Omicron subvariant #BA2 now seems to be surging nationwide (pink), especially in the coastal regions of the Us the fastest. This means it’s not a fluke increase. US’s #BA2 trend will follow Europe’s rise for sure. pic.twitter.com/VwuUFGd8k7
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
3) I’ve been worried about #BA2 for a while. In 3rd week of January, it was rising in Denmark— it’s now near total dominant in Denmark. https://t.co/U5rafo56ko
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
4) Multiple studies show the #BA2 subvariant is much faster transmission than old Omicron. Some say 30% some say ~90-120%, and some say 150% (1.5 time more). https://t.co/tQWaPxjuzu
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
5) Who said #BA2 is 1.5 times more contagious? Denmark’s CDC @SSI_dk said so—and they warned it was extending Denmark’s Omicron wave much longer. Same thing is going to happen in the US which is much much less vaccinated. https://t.co/U3HU1U3kaP
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
6) other tricky thing is that #Omicron #Ba2’s PCR looks like almost any other non-BA1 Omicron because the SGTF shortcut PCR won’t work on BA2. Thus it’s hard to tell apart BA2 from Delta variant without genome 🧬 sequencing. https://t.co/AUWIuGvouH
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
7) Virus researcher & chief physician of 🇩🇰’s CDC @ssi_dk says you can get **reinfected with #BA2 sub-variant** of #Omicron after being infected with Omicron BA.1. ➡️ This is why we shouldn’t risk COVID or chase mass infection. https://t.co/e73Ti9o24H pic.twitter.com/T1KWQrpBno
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
8) It’s also surging in UK 🇬🇧 as well. #Ba2 d doubled in one week. It’s also surging in Netherlands and in Germany and elsewhere. It’s everywhere now- and quickly displacing the old Omicron 1.0. https://t.co/aSj89lEpp6
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
9) How different is #Omicron BA2 from BA1? #BA2 has **17 additional mutations** that BA1 doesn’t have! There is also a BA3 but that one doesn’t have much difference beyond BA1 and BA2.
HT @WmHaseltine pic.twitter.com/hugNPA0UIH
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
10) Notably, “Each of BA1/2/3 variants is as different from one another as Alpha, Beta, Gamma, and Delta are from one another”! says @WmHaseltine pic.twitter.com/EgYBPo79h5
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
11) BA2 #Omicron is not a child-lineage of BA1 #Omicron. They are more like “cousins” that branched off earlier – hence they are much more different than parent-child versions of each other. This is also why reinfections could be higher. pic.twitter.com/LKWa5F3Uqr
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
12) If you still have any doubt in your mind about #BA2 being a 2.0 Omicron that will displace the old Omicron and cause a new surge— just look at how #BA2 (aka ‘Omicron 21L’ in the charts) is surging like mad across multiple countries (& this is just late Jan data!). Get ready. pic.twitter.com/V5MdnhoO70
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
13) 🇬🇧 data also shows a higher secondary attack rate in households for #BA2 versus the old BA1 Omicron. And the growth rate is indeed more than doubling per week. Exponential rise will beget exponential trouble – earlier Omicron immunity clearly isn’t slowing it much—not good. https://t.co/8srSJkq090
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
14) Now the real bad news— two new studies say “immunity based on #Omicron-infection is weak for (another) Omicron reinfection” — if unvaccinated ⚠️
This means protection from your earlier Omicron may not be great if unvaccinated! 👀 https://t.co/lMlxdpiiq4
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
15) Some relatively good news on #BA2 is that it seems to responds similarly to vaccines as BA1– but it responds well only to 3 vaccine shots if you get a booster. Without booster, the symptomatic efficacy is very poor —13% and that’s not even significantly different from 0. https://t.co/L9bEMX8ZGB
— Eric Feigl-Ding (@DrEricDing) February 9, 2022
今度は、BA.1とBA.2の合体変異株ですか。そうですか。https://t.co/sCxZFosycU
— Junichi YANANOSE (@pluredro) February 21, 2022
なんかまた微妙に違うやつが見つかったっぽい。https://t.co/nsenG0uo6b
— Junichi YANANOSE (@pluredro) February 21, 2022
フィンランドでも、BA.1とBA.2の合体変異株と思われるものが見つかったそうです。https://t.co/8Gnap6jWt9
— Junichi YANANOSE (@pluredro) February 21, 2022
SARS-CoV-2 は脳、心臓、肺、血液、精巣、結腸、肝臓、リンパ節を攻撃し、長期的な障害を誘発する複数の感染経路を持つ全身性疾患であり、半年で患者の半数以上に持続的な症状を引き起こす・・・
SARS-CoV-2 #コロナ は脳、心臓、肺、血液、精巣、結腸、肝臓、リンパ節を攻撃し、長期的な障害を誘発する複数の感染経路を持つ全身性疾患であり、半年で患者の半数以上に持続的な症状を引き起こすします。
（4 /🧵） https://t.co/ycgQWl1YGk— TweetViewer 優しさを大切にする隠者 (@TweetViewer3) January 8, 2022
SARS-CoV-2 is a systemic disease which has multiple avenues to induce long-term impairment, attacking the brain, heart, lungs, blood, testes, colon, liver, and lymph nodes, causing persistent symptoms in more than half of patients by six months out.
(4/🧵)pic.twitter.com/192TnhELQe— Ian Ricksecker 🇺🇸🇺🇦🇪🇺🌍 (@IanRicksecker) January 5, 2022
おそらく最も恐ろしい研究は、長期のコロナ症状に対するワクチン接種の効果を調べたオックスフォード大学からのものでしょう。なぜなら、ワクチンがコロナ後遺症を予防しないだけでなく、コロナ後遺症の症状が時間の経過と共に起こり易くなることが分かったのです:
(40 /🧵)https://t.co/AZgiHkShzf— TweetViewer 優しさを大切にする隠者 (@TweetViewer3) January 9, 2022
Perhaps the most terrifying study is from Oxford University, which examined the effects of vaccination on long COVID symptoms, because not only did it find that vaccination does not protect against Long Covid, but that Long Covid symptoms become more likely over time:
(40/🧵) pic.twitter.com/rFwvTImnSR— Ian Ricksecker 🇺🇸🇺🇦🇪🇺🌍 (@IanRicksecker) January 5, 2022