疫学的にヤバいのは感染速度の早いウイルス、致死率が中途半端に低い感染症のほうがよっぽどヤバい

投稿日投稿者しとらす

ラモス[@ramos262740691]さんのスレッドを読んでいて、そりゃそ～だとしか

ο株の登場以降、特に世代交代を繰り返してパワーアップしたBQ系統・XBB系統なんて、1度感染しても自然免疫ができずに再感染なんて話をよく目にするようになったので、キラー治療薬が開発されるまでは、鼻腔や上咽頭に付着したウイルスを速やかかつ物理的に洗い流して感染を防ぐしかないかな〜と考えてます。
在宅ワーカーの私は外出から戻ってきたら、着ていた衣類は全部洗濯して、

石鹸で手と顔を洗う→洗眼→生理食塩水で鼻うがい→（内科で出してもらった薬剤で）うがい

を1年以上続けています。宅配の人とか来訪者と顔を合わせた直後にも鼻うがいをしてます。
あと週に2〜3回は京都の街中にある無料PCR検査を受診。
これでずっと陰性だったのでワクチン接種より正解なのでしょう。
念の為HEPA付の空気清浄機を買った。
鼻うがいはノーズシャワーという器具（この350mlボトルに小さじ1杯弱の食塩で生理食塩水の出来上がり）。

 

◆Does SARS-CoV-2 Affect Human Semen? A Systematic Review and Meta-Analysis【SpringerLink　2023年1月5日】

Abstract

Contradictory results have been reported regarding effects of the SARS-CoV-2 upon human semen. A timely and up-to-date systematic review with meta-analysis appears necessary. This study aimed to deliver pooled prevalence (PP) of SARS-CoV-2 in semen and pooled semen parameters as compared with the uninfected. The relevant databases were scanned by two authors for observational studies reporting analysis of semen in COVID-19 patients. The SARS-CoV-2-infected were assigned to group A (exposed arm), whereas the uninfected to group B (unexposed arm). Newcastle–Ottawa Scale was used to address the risk of bias. PRISMA guidelines were adopted. In case of homogenous studies, fixed-effects model was followed, whereas for heterogenous studies random-effects model was used. Of 990 studies, 24 were eligible involving 1589 subjects (947 in group A and 642 in group B). The “comparability” domain was biased the most. SARS-CoV-2 RNA was detected in three studies among 8 individuals producing the PP of 1.76% (95% CI 0.72–3.21). Sperm concentration was reduced significantly (WMD = –16.23 [95% CI –25.56 to –6.89], as well as total sperm in ejaculate (WMD = –34.84 [95% CI − 43.51 to –26.17]) and sperm volume (WMD =  − 0.48 [95% CI − 0.59 to − 0.36] in group A as compared with controls. There was a non-significant effect upon progressive motility and leukocyte presence in semen. SARS-CoV-2 RNA in semen among the infected individuals is detected infrequently. By this token, sexual transmission through semen is of low probability and little concern for public health. However, significant decrease in sperm volume, sperm concentration, and total sperm in ejaculate has been noted. The current data, though, are limited, and more studies with longer follow-up are needed to evaluate the further impact.

Introduction

An unprecedented scale of the global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has propelled researchers throughout the world to identify routes of its transmission. As the virus predominantly causes respiratory tract disease officially called coronavirus disease 2019 (COVID-19), it chiefly spreads through respiratory droplets during face-to-face contact with an infected subject. The disease, which until September 4, 2022, was declared in over 600 million cases with almost 6.5 million casualties worldwide (World Health Organization, https://covid19.who.int/), has also been of concern in terms of other organs and systems. By means of real-time reverse transcription polymerase chain reaction (rRT-PCR), viral nucleic acid was detected in nasal, nasopharyngeal, and pharyngeal smears, samples of saliva, blood, stool, urine, and tears (Karia et al., 2020; W. Wang et al., 2020). Regarding male reproductive tract, studies have been emerging focusing on possible presence of the viral RNA in semen and on the impact of COVID-19 upon semen characteristics (Cipriano et al., 2020; Holtmann et al., 2020; Temiz et al., 2021). Cell entry is facilitated by the viral spike protein and cellular angiotensin-converting enzyme 2 (ACE2) interaction (W. Li et al., 2003). Abundance of this enzyme in testes could possibly account for the viral appearance in semen and potentially another route of transmission. As new research has been conducted on the topic, an updated systematic review with meta-analysis is desired. Hence, the aim of this study is to perform the most comprehensive systematic review with statistical approach of the observational studies analyzing SARS-CoV-2 RNA in semen and sperm characteristics (sperm concentration, total sperm in ejaculate, volume, sperm motility, and presence of leukocytes). The following null hypotheses were stated: (1) 95% confidence intervals (CI) of weighted mean differences (WMD) of continuous variables encompasses 0 and 95% CI of risk ratio (RR) of binary variables includes 1 indicating SARS-CoV-2 and COVID-19 do not affect semen quality. (2) SARS-CoV-2 RNA in human semen is undetectable or its prevalence is negligible.